Discover Our Work

2026

Hypothalamic prolactin receptor+ dopaminergic neurons regulate energy metabolism and nociceptive threshold in mice during lactation

Nature Communications, August 2026

Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice

Nature Communications, July 2026

TGF-β-induced fibrotic scar formation limits recovery of spinal cord injury

Bone Research, February 2026

PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice

Nature, January 2026

2025

Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis

Nature Aging, July 2025

Hypothalamus Regulates Anabolic Metabolism of Articular Cartilage Superficial Chondrocytes through PGE2 Skeletal Interoception

Advanced Science, March 2025

Characterizing a new rat model of chronic pain after spine surgery

Nature, March 2025

Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study

Skeletal Radiology, January 2025

2024

Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative

Osteoporosis & Cartilage, September 2024

Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

eLife Sciences, December 2024

Proton-activated chloride channel increases endplate porosity and pain in a mouse spine degeneration model

Journal of Clinical Investigations, August 2024

Senescence of endplate osteoclasts induces sensory innervation and spinal pain
eLife Sciences, June 2024

Brain Regulates Weight Bearing Bone through PGE2 Skeletal Interoception: Implication of Ankle Osteoarthritis and Pain

Bone Research, March 2024

2023

Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration

Science Translational Medicine, November 2023

Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism

Advanced Science, October 2023

Statin use and longitudinal changes in quantitative MRI-based biomarkers of thigh muscle quality: data from Osteoarthritis Initiative

Skeletal Radiology, October 2023

Bone-derived PDGF-BB drives brain vascular calcification in male mice

Journal of Clinical Investigations, October 2023

Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort

Journal of Cachexia, Sarcopenia & Muscle, June 2024

RANK+TLR2+ myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis

eLife Sciences, May 2023

Chronic pain after spine surgery: Insights into pathogenesis, new treatment, and preventive therapy

Journal of Orthopaedic Translation, September 2023

Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation

Advanced Science, April 2023

Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRb Shedding from Pericytes

Advanced Science, April 2023

Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow

Cell Metabolism, April 2023

Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion

Bone Research, May 2023